Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine

Anticancer phospholipids that inhibit Akt such as the alkylphospholipid perifosine (Per) and phosphatidylinositol ether lipid analogs (PIAs) promote cellular detachment and apoptosis and have a similar cytotoxicity profile against cancer cell lines in the NCI60 panel. While investigating the mechani...

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Dettagli Bibliografici
Autori principali: Gills, J J, Zhang, C, Abu-Asab, M S, Castillo, S S, Marceau, C, LoPiccolo, J, Kozikowski, A P, Tsokos, M, Goldkorn, T, Dennis, P A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406576/
https://ncbi.nlm.nih.gov/pubmed/22764099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.72
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