Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

mTOR inhibitors are used clinically to treat renal cancer but are not curative. Here we show that autophagy is a resistance mechanism of human renal cell carcinoma (RCC) cell lines to mTOR inhibitors. RCC cell lines have high basal autophagy that is required for survival to mTOR inhibition. In RCC4...

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Bibliografiske detaljer
Main Authors: Bray, Kevin, Mathew, Robin, Lau, Alexandria, Kamphorst, Jurre J., Fan, Jing, Chen, Jim, Chen, Hsin-Yi, Ghavami, Anahita, Stein, Mark, DiPaola, Robert S., Zhang, Donna, Rabinowitz, Joshua D., White, Eileen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406086/
https://ncbi.nlm.nih.gov/pubmed/22848625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041831
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