Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans containing sialic acid (Neu5Ac) may play a role in MCPyV infectious entry. To addres...

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Hauptverfasser: Neu, Ursula, Hengel, Holger, Blaum, Bärbel S., Schowalter, Rachel M., Macejak, Dennis, Gilbert, Michel, Wakarchuk, Warren W., Imamura, Akihiro, Ando, Hiromune, Kiso, Makoto, Arnberg, Niklas, Garcea, Robert L., Peters, Thomas, Buck, Christopher B., Stehle, Thilo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406085/
https://ncbi.nlm.nih.gov/pubmed/22910713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002738
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