Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans containing sialic acid (Neu5Ac) may play a role in MCPyV infectious entry. To addres...

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Detaylı Bibliyografya
Asıl Yazarlar: Neu, Ursula, Hengel, Holger, Blaum, Bärbel S., Schowalter, Rachel M., Macejak, Dennis, Gilbert, Michel, Wakarchuk, Warren W., Imamura, Akihiro, Ando, Hiromune, Kiso, Makoto, Arnberg, Niklas, Garcea, Robert L., Peters, Thomas, Buck, Christopher B., Stehle, Thilo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406085/
https://ncbi.nlm.nih.gov/pubmed/22910713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002738
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