Regulation of mitochondrial permeability transition pore by PINK1

BACKGROUND: Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear. We previously reported that loss of PINK1 impairs mitochondrial respiratory activity in mouse brains. RESULTS: In this st...

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Bibliografiske detaljer
Main Authors: Giaime, Emilie, Caballero, Erica, Núñez, Lucía, Song, Zhiyin, Chan, David, Villalobos, Carlos, Shen, Jie
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405481/
https://ncbi.nlm.nih.gov/pubmed/22630785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-22
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