The KCNQ1-KCNE2 K(+) channel is required for adequate thyroid I(−) uptake

The KCNQ1 α subunit and the KCNE2 β subunit form a potassium channel in thyroid epithelial cells. Genetic disruption of KCNQ1-KCNE2 causes hypothyroidism in mice, resulting in cardiac hypertrophy, dwarfism, alopecia, and prenatal mortality. Here, we investigated the mechanistic requirement for KCNQ1...

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Main Authors: Purtell, Kerry, Paroder-Belenitsky, Monika, Reyna-Neyra, Andrea, Nicola, Juan P., Koba, Wade, Fine, Eugene, Carrasco, Nancy, Abbott, Geoffrey W.
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405278/
https://ncbi.nlm.nih.gov/pubmed/22549510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-206110
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