Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo

Apoptosis of post-mitotic neurons plays a significant role in secondary tissue damage following traumatic spinal cord injury (SCI). Activation of E2F1-dependent transcription promotes expression of pro-apoptotic factors, including CDK1; this signal transduction pathway is believed to represent an im...

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Autors principals: Wu, Junfang, Kharebava, Giorgi, Piao, Chunshu, Stoica, Bogdan A., Dinizo, Michael, Sabirzhanov, Boris, Hanscom, Marie, Guanciale, Kelsey, Faden, Alan I.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405037/
https://ncbi.nlm.nih.gov/pubmed/22848730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042129
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