IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia

BACKGROUND: Deletions of IKAROS (IKZF1) frequently occur in B-cell precursor acute lymphoblastic leukemia (B-ALL) but the mechanisms by which they influence pathogenesis are unclear. To address this issue, a cohort of 144 adult B-ALL patients (106 BCR-ABL1-positive and 38 B-ALL negative for known mo...

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Detalhes bibliográficos
Main Authors: Iacobucci, Ilaria, Iraci, Nunzio, Messina, Monica, Lonetti, Annalisa, Chiaretti, Sabina, Valli, Emanuele, Ferrari, Anna, Papayannidis, Cristina, Paoloni, Francesca, Vitale, Antonella, Storlazzi, Clelia Tiziana, Ottaviani, Emanuela, Guadagnuolo, Viviana, Durante, Sandra, Vignetti, Marco, Soverini, Simona, Pane, Fabrizio, Foà, Robin, Baccarani, Michele, Müschen, Markus, Perini, Giovanni, Martinelli, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405023/
https://ncbi.nlm.nih.gov/pubmed/22848414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040934
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