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Induction of Heme Oxygenase-1 Inhibits Cell Death in Crotonaldehyde-Stimulated HepG2 Cells via the PKC-δ -p38 -Nrf2 Pathway

BACKGROUND: Crotonaldehyde, an alpha, beta-unsaturated aldehyde present in cigarette smoke, is an environmental pollutant and a product of lipid peroxidation. It also produces adverse effects to humans and is considered as a risk factor for various diseases. Heme oxygenase-1 (HO-1) plays important r...

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Autores principales: Lee, Seung Eun, Yang, Hana, Jeong, Seong Il, Jin, Young-Ho, Park, Cheung-Seog, Park, Yong Seek
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405012/
https://ncbi.nlm.nih.gov/pubmed/22848562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041676
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