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6-shogaol attenuates H(2)O(2)-induced oxidative stress via upregulation of Nrf2-mediated γ-glutamylcysteine synthetase and heme oxygenase expression in HepG2 cells

The signaling pathway by which 6-shogaol protects HepG2 cells against H(2)O(2)-induced oxidative stress was investigated. Cellular anti-oxidant activities, the GSH level, and anti-oxidant response element (ARE) promoter activity were analyzed. Activated protein kinases and nuclear transcription fact...

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Pubblicato in:Food Sci Biotechnol
Autori principali: Kim, Jin-Kyoung, Jang, Hae-Dong
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Korean Society of Food Science and Technology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049361/
https://ncbi.nlm.nih.gov/pubmed/30263273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10068-016-0045-3
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