Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

Failure of elimination of amyloid-β (Aβ) from the brain and vasculature appears to be a key factor in the etiology of sporadic Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA). In addition to age, possession of an apolipoprotein E (APOE) ε4 allele is a strong risk factor for the develo...

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Hlavní autoři: Hawkes, Cheryl A., Sullivan, Patrick M., Hands, Sarah, Weller, Roy O., Nicoll, James A. R., Carare, Roxana O.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404985/
https://ncbi.nlm.nih.gov/pubmed/22848551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041636
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