Combination of gastrin-releasing peptide antagonist with cytotoxic agents produces synergistic inhibition of growth of human experimental colon cancers

We investigated the efficacy of a powerful antagonist of bombesin/gastrin-releasing peptide (BN/GRP) RC-3940-II administered as a single agent or in combination with cytotoxic agents on the growth of HT-29, HCT-116 and HCT-15 human colon cancer in vitro and in vivo. GRP-receptor mRNA and protein wer...

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Main Authors: Rick, Ferenc G., Buchholz, Stefan, Schally, Andrew V., Szalontay, Luca, Krishan, Awtar, Datz, Christian, Stadlmayr, Andreas, Aigner, Elmar, Perez, Roberto, Seitz, Stephan, Block, Norman L., Hohla, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404878/
https://ncbi.nlm.nih.gov/pubmed/22751419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20900
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