GHRH antagonist when combined with cytotoxic agents induces S-phase arrest and additive growth inhibition of human colon cancer

Treatment of colon cancer with an antagonist of growth hormone-releasing hormone (GHRH), JMR-132, results in a cell cycle arrest in S-phase of the tumor cells. Thus, we investigated the effect of JMR-132 in combination with S-phase-specific cytotoxic agents, 5-FU, irinotecan and cisplatin on the in...

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Hlavní autoři: Rick, Ferenc G., Seitz, Stephan, Schally, Andrew V., Szalontay, Luca, Krishan, Awtar, Datz, Christian, Stadlmayr, Andreas, Buchholz, Stefan, Block, Norman L., Hohla, Florian
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524216/
https://ncbi.nlm.nih.gov/pubmed/23095641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22498
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