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Actinomycin D facilitates transition of AT domains in molecules of sequence (AT)nAGCT(AT)n to a DNAse I detectable alternating structure.

The interaction of actinomycin D with (AT)nAGCT(AT)n (where n = 2, 3, or 4) was investigated using a combination of imino proton NMR and DNAse I digestion. The stoichiometry of the interaction appears to be one:one with the actinomycin chromophore intercalated between the two GC base pairs. This bin...

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Autors principals: Lane, M J, Laplante, S, Rehfuss, R P, Borer, P N, Cantor, C R
Format: Artigo
Idioma:Inglês
Publicat: 1987
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC340471/
https://ncbi.nlm.nih.gov/pubmed/3822817
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