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Robust expansion of human hepatocytes in Fah(−/−)/Rag2(−/−)/Il2rg (−/−) mice

Mice that could be highly repopulated with human hepatocytes would have many potential uses in drug development and research applications. The best available model of liver humanization, the uroplasminogen-activator transgenic model, has major practical limitations. To provide a broadly useful hepat...

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Detalhes bibliográficos
Main Authors: Azuma, Hisaya, Paulk, Nicole, Ranade, Aarati, Dorrell, Craig, Al-Dhalimy, Muhsen, Ellis, Ewa, Strom, Stephen, Kay, Mark A, Finegold, Milton, Grompe, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404624/
https://ncbi.nlm.nih.gov/pubmed/17664939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1326
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