Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(−/−) mice fed low levels of cholic acid

Cholesterol 7α-hydroxylase (CYP7A1) is the initiating and rate-limiting enzyme in the neutral pathway that coverts cholesterol to primary bile acids (BA). CYP7A1-deficient (Cyp7a1(−/−)) mice have a depleted BA pool, diminished intestinal cholesterol absorption, accelerated fecal sterol loss, and inc...

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Detalhes bibliográficos
Main Authors: Jones, Ryan D., Repa, Joyce J., Russell, David W., Dietschy, John M., Turley, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404571/
https://ncbi.nlm.nih.gov/pubmed/22628034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00111.2012
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