The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F tra...

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Autors principals: Aksoy, Ozlem, Chicas, Agustin, Zeng, Tianying, Zhao, Zhen, McCurrach, Mila, Wang, Xiaowo, Lowe, Scott W.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404383/
https://ncbi.nlm.nih.gov/pubmed/22802529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.196238.112
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