Antitumoral Efficacy of the Protease Inhibitor Gabexate Mesilate in Colon Cancer Cells Harbouring KRAS, BRAF and PIK3CA Mutations

The employment of anti-epidermal growth factor receptor (EGFR) antibodies represents a backbone of the therapeutic options for the treatment of metastatic colorectal cancer (mCRC). However, this therapy is poorly effective or ineffective in unselected patients. Mutations in KRAS, BRAF and PIK3CA gen...

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Bibliografiske detaljer
Main Authors: Brandi, Giovanni, Tavolari, Simona, De Rosa, Francesco, Di Girolamo, Stefania, Agostini, Valentina, Barbera, Maria Aurelia, Frega, Giorgio, Biasco, Guido
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404056/
https://ncbi.nlm.nih.gov/pubmed/22911782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041347
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