The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer

BACKGROUND: Mutations in KRAS, BRAF, PIK3CA and PTEN expression have been in focus to predict the effect of epidermal growth factor receptor-blocking therapy in colorectal cancer (CRC). Here, information on these four aberrations was collected and combined to a Quadruple index and used to evaluate t...

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Detalhes bibliográficos
Main Authors: Eklöf, V, Wikberg, M L, Edin, S, Dahlin, A M, Jonsson, B-A, Öberg, Å, Rutegård, J, Palmqvist, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670497/
https://ncbi.nlm.nih.gov/pubmed/23660947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.212
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