Antitumoral Efficacy of the Protease Inhibitor Gabexate Mesilate in Colon Cancer Cells Harbouring KRAS, BRAF and PIK3CA Mutations

The employment of anti-epidermal growth factor receptor (EGFR) antibodies represents a backbone of the therapeutic options for the treatment of metastatic colorectal cancer (mCRC). However, this therapy is poorly effective or ineffective in unselected patients. Mutations in KRAS, BRAF and PIK3CA gen...

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Main Authors: Brandi, Giovanni, Tavolari, Simona, De Rosa, Francesco, Di Girolamo, Stefania, Agostini, Valentina, Barbera, Maria Aurelia, Frega, Giorgio, Biasco, Guido
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404056/
https://ncbi.nlm.nih.gov/pubmed/22911782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041347
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