Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study

BACKGROUND: The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant ovarian cancer. METHODS: Preclinical in vitro platinum-resistant ovarian cance...

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Autori principali: Kunos, Charles, Radivoyevitch, Tomas, Abdul-Karim, Fadi W, Fanning, James, Abulafia, Ovadia, Bonebrake, Albert J, Usha, Lydia
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403898/
https://ncbi.nlm.nih.gov/pubmed/22541066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-79
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