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Ribonucleotide Reductase Inhibition Enhances Chemoradiosensitivity of Human Cervical Cancers
For repair of damaged DNA, cells increase de novo synthesis of deoxyribonucleotide triphosphates through the rate-limiting, p53-regulated ribonucleotide reductase (RNR) enzyme. In this study we investigated whether pharmacological inhibition of RNR by 3-aminopyridine-2-carboxaldehyde thiosemicarbazo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3529744/ https://ncbi.nlm.nih.gov/pubmed/20954859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR2273.1 |
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