Phosphorylation of HSP27 by Protein Kinase D Is Essential for Mediating Neuroprotection against Ischemic Neuronal Injury

Heat shock protein 27 (HSP27) (or HSPB1) exerts cytoprotection against many cellular insults, including cerebral ischemia. We previously identified apoptosis signal-regulating kinase 1 (ASK1) as a critical downstream target of HSP27 conferring the neuroprotective effects of HSP27 against neuronal is...

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Detalhes bibliográficos
Main Authors: Stetler, R. Anne, Gao, Yanqin, Zhang, Lili, Weng, Zhongfang, Zhang, Feng, Hu, Xiaoming, Wang, Suping, Vosler, Peter, Cao, Guodong, Sun, Dandan, Graham, Steven H., Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403749/
https://ncbi.nlm.nih.gov/pubmed/22357851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5169-11.2012
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