Hsp27 Protects against Ischemic Brain Injury via Attenuation of a Novel Stress-Response Cascade Upstream of Mitochondrial Cell Death Signaling

Heat shock protein 27 (Hsp27), a recently discovered member of the heat shock protein family, is markedly induced in the brain after cerebral ischemia and other injury states. In non-neuronal systems, Hsp27 has potent cell death-suppressing functions. However, the mechanism of Hsp27-mediated neuropr...

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Main Authors: Stetler, R. Anne, Cao, Guodong, Gao, Yanqin, Zhang, Feng, Wang, Suping, Weng, Zhongfang, Vosler, Peter, Zhang, Lili, Signore, Armando, Graham, Steven H., Chen, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614130/
https://ncbi.nlm.nih.gov/pubmed/19052195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4407-08.2008
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