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Apolipoprotein E: Essential Catalyst of the Alzheimer Amyloid Cascade

The amyloid cascade hypothesis remains a robust model of AD neurodegeneration. However, amyloid deposits contain proteins besides Aβ, such as apolipoprotein E (apoE). Inheritance of the apoE4 allele is the strongest genetic risk factor for late-onset AD. However, there is no consensus on how differe...

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Détails bibliographiques
Auteurs principaux: Potter, Huntington, Wisniewski, Thomas
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403541/
https://ncbi.nlm.nih.gov/pubmed/22844635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/489428
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