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Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by extracellular amyloid-ß (Aß) and intraneuronal tau protein brain pathologies. The most significant risk factor for non-familial AD is the presence of the E4 isoform of the cholesterol transporter apolipoprotein...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3506946/ https://ncbi.nlm.nih.gov/pubmed/22929359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt135 |
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