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The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step in mRNA decay, as well as roles in th...

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Détails bibliographiques
Auteurs principaux: Brook, Matthew, Gray, Nicola K.
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403503/
https://ncbi.nlm.nih.gov/pubmed/22817748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20120100
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