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mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation

Translation and mRNA stability are enhanced by the presence of a poly(A) tail. In vivo, the tail interacts with a conserved polypeptide, poly(A) binding protein (Pab1p). To examine Pab1p function in vivo, we have tethered Pab1p to the 3′ UTR of reporter mRNAs by fusing it to MS2 coat protein and pla...

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Udgivet i:Genes Dev
Principais autores: Coller, Jeffery M., Gray, Nicola K., Wickens, Marvin P.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317214/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9784497/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.20.3226
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