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Glu121-Lys319 salt bridge between catalytic and N-terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N

Escherichia coli aminopeptidase N (ePepN) belongs to the gluzincin family of M1 class metalloproteases that share a common primary structure with consensus zinc binding motif (HEXXH-(X18)-E) and an exopeptidase motif (GXMEN) in the active site. There is one amino acid, E121 in Domain I that blocks t...

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Autors principals: Gumpena, Rajesh, Kishor, Chandan, Ganji, Roopa Jones, Jain, Nishant, Addlagatta, Anthony
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403470/
https://ncbi.nlm.nih.gov/pubmed/22411732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2060
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