Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could successfully model age-related diseases such as Parkinson's disease (PD). Here, we generated iPSC lines from seven patients with idiopathi...

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Hlavní autoři: Sánchez-Danés, Adriana, Richaud-Patin, Yvonne, Carballo-Carbajal, Iria, Jiménez-Delgado, Senda, Caig, Carles, Mora, Sergio, Di Guglielmo, Claudia, Ezquerra, Mario, Patel, Bindiben, Giralt, Albert, Canals, Josep M, Memo, Maurizio, Alberch, Jordi, López-Barneo, José, Vila, Miquel, Cuervo, Ana Maria, Tolosa, Eduard, Consiglio, Antonella, Raya, Angel
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2012
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403296/
https://ncbi.nlm.nih.gov/pubmed/22407749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200215
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