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Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development
The transcription factors Nanog and Gata6 are critical to specify the epiblast versus primitive endoderm (PrE) lineages. However, little is known about the mechanisms that regulate the protein stability and activity of these factors in the developing embryo. Here we uncover an early developmental fu...
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| Glavni autori: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3403013/ https://ncbi.nlm.nih.gov/pubmed/22713603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.188193.112 |
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