Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development

The transcription factors Nanog and Gata6 are critical to specify the epiblast versus primitive endoderm (PrE) lineages. However, little is known about the mechanisms that regulate the protein stability and activity of these factors in the developing embryo. Here we uncover an early developmental fu...

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Autori principali: Lavial, Fabrice, Bessonnard, Sylvain, Ohnishi, Yusuke, Tsumura, Akiko, Chandrashekran, Anil, Fenwick, Mark A., Tomaz, Rute A., Hosokawa, Hiroyuki, Nakayama, Toshinori, Chambers, Ian, Hiiragi, Takashi, Chazaud, Claire, Azuara, Véronique
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2012
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403013/
https://ncbi.nlm.nih.gov/pubmed/22713603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.188193.112
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