Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development

The transcription factors Nanog and Gata6 are critical to specify the epiblast versus primitive endoderm (PrE) lineages. However, little is known about the mechanisms that regulate the protein stability and activity of these factors in the developing embryo. Here we uncover an early developmental fu...

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Detalhes bibliográficos
Main Authors: Lavial, Fabrice, Bessonnard, Sylvain, Ohnishi, Yusuke, Tsumura, Akiko, Chandrashekran, Anil, Fenwick, Mark A., Tomaz, Rute A., Hosokawa, Hiroyuki, Nakayama, Toshinori, Chambers, Ian, Hiiragi, Takashi, Chazaud, Claire, Azuara, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403013/
https://ncbi.nlm.nih.gov/pubmed/22713603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.188193.112
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