Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature

Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by myokymia and attacks of ataxic gait often precipitated by stress. Several genetic mutations have been identified in the Shaker-like K(+) channel Kv1.1 (KCNA1) of EA1 individuals, including V408A, which resul...

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Hlavní autoři: Brunetti, Orazio, Imbrici, Paola, Botti, Fabio Massimo, Pettorossi, Vito Enrico, D'Adamo, Maria Cristina, Valentino, Mario, Zammit, Christian, Mora, Marina, Gibertini, Sara, Di Giovanni, Giuseppe, Muscat, Richard, Pessia, Mauro
Médium: Artigo
Jazyk:Inglês
Vydáno: Academic Press 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402927/
https://ncbi.nlm.nih.gov/pubmed/22609489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.05.002
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