Corticosteroids and β(2)-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms

BACKGROUND AND PURPOSE: Airway remodelling is a consequence of long-term inflammation and MAPKs are key signalling molecules that drive pro-inflammatory pathways. The endogenous MAPK deactivator – MAPK phosphatase 1 (MKP-1) – is a critical negative regulator of the myriad pro-inflammatory pathways a...

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Библиографические подробности
Главные авторы: Manetsch, M, Ramsay, EE, King, EM, Seidel, P, Che, W, Ge, Q, Hibbs, DE, Newton, R, Ammit, AJ
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2012
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402770/
https://ncbi.nlm.nih.gov/pubmed/22372570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01923.x
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