Long-Acting β(2)-Agonists Increase Fluticasone Propionate-Induced Mitogen-Activated Protein Kinase Phosphatase 1 (MKP-1) in Airway Smooth Muscle Cells

Mitogen-activated protein kinase phosphatase 1 (MKP-1) represses MAPK-driven signalling and plays an important anti-inflammatory role in asthma and airway remodelling. Although MKP-1 is corticosteroid-responsive and increased by cAMP-mediated signalling, the upregulation of this critical anti-inflam...

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Hlavní autoři: Manetsch, Melanie, Rahman, Md. Mostafizur, Patel, Brijeshkumar S., Ramsay, Emma E., Rumzhum, Nowshin N., Alkhouri, Hatem, Ge, Qi, Ammit, Alaina J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606114/
https://ncbi.nlm.nih.gov/pubmed/23533638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059635
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