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The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA

Sphingosine 1-phosphate, a bioactive signaling molecule with diverse cellular functions, is irreversibly degraded by the endoplasmic reticulum enzyme sphingosine 1-phosphate lyase, generating trans-2-hexadecenal and phosphoethanolamine. We recently demonstrated that trans-2-hexadecenal causes cytosk...

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Autors principals: Upadhyaya, Pramod, Kumar, Ashok, Byun, Hoe-Sup, Bittman, Robert, Saba, Julie D., Hecht, Stephen S.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402648/
https://ncbi.nlm.nih.gov/pubmed/22727907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.06.012
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