The COX-2/PGI2 Receptor Axis Plays an Obligatory Role in Mediating the Cardioprotection Conferred by the Late Phase of Ischemic Preconditioning

BACKGROUND: Pharmacologic studies with cyclooxygenase-2 (COX-2) inhibitors suggest that the late phase of ischemic preconditioning (PC) is mediated by COX-2. However, nonspecific effects of COX-2 inhibitors cannot be ruled out, and the selectivity of these inhibitors for COX-2 vs. COX-1 is only rela...

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Autores principales: Guo, Yiru, Tukaye, Deepali Nivas, Wu, Wen-Jian, Zhu, Xiaoping, Book, Michael, Tan, Wei, Jones, Steven P., Rokosh, Gregg, Narumiya, Shuh, Li, Qianhong, Bolli, Roberto
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402528/
https://ncbi.nlm.nih.gov/pubmed/22844439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041178
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