Activation of Soluble Adenylyl Cyclase Protects against Secretagogue Stimulated Zymogen Activation in Rat Pancreaic Acinar Cells

An early feature of acute pancreatitis is activation of zymogens, such as trypsinogen, within the pancreatic acinar cell. Supraphysiologic concentrations of the hormone cholecystokinin (CCK; 100 nM), or its orthologue cerulein (CER), induce zymogen activation and elevate levels of cAMP in pancreatic...

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Main Authors: Kolodecik, Thomas R., Shugrue, Christine A., Thrower, Edwin C., Levin, Lonny R., Buck, Jochen, Gorelick, Fred S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402497/
https://ncbi.nlm.nih.gov/pubmed/22844459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041320
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