Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma

BACKGROUND: Severe asthma accounts for a small number of asthmatics but represents a disproportionate cost to health care systems. The underlying mechanism in severe asthma remains unknown but several mechanisms are likely to be involved because of a very heterogeneous profile. We investigated the e...

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Bibliographic Details
Main Authors: Mercado, Nicolas, Hakim, Amir, Kobayashi, Yoshiki, Meah, Sally, Usmani, Omar S., Chung, Kian Fan, Barnes, Peter J., Ito, Kazuhiro
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402424/
https://ncbi.nlm.nih.gov/pubmed/22911818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041582
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