Growth-Dependent Podocyte Failure Causes Glomerulosclerosis

Podocyte depletion leads to glomerulosclerosis, but whether an impaired capacity of podocytes to respond to hypertrophic stress also causes glomerulosclerosis is unknown. We generated transgenic Fischer 344 rats that express a dominant negative AA-4E-BP1 transgene driven by the podocin promoter; a m...

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Detalhes bibliográficos
Main Authors: Fukuda, Akihiro, Chowdhury, Mahboob A., Venkatareddy, Madhusudan P., Wang, Su Q., Nishizono, Ryuzoh, Suzuki, Tsukasa, Wickman, Larysa T., Wiggins, Jocelyn E., Muchayi, Timothy, Fingar, Diane, Shedden, Kerby A., Inoki, Ken, Wiggins, Roger C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402293/
https://ncbi.nlm.nih.gov/pubmed/22773827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012030271
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