Growth-Dependent Podocyte Failure Causes Glomerulosclerosis

Podocyte depletion leads to glomerulosclerosis, but whether an impaired capacity of podocytes to respond to hypertrophic stress also causes glomerulosclerosis is unknown. We generated transgenic Fischer 344 rats that express a dominant negative AA-4E-BP1 transgene driven by the podocin promoter; a m...

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Bibliografski detalji
Glavni autori: Fukuda, Akihiro, Chowdhury, Mahboob A., Venkatareddy, Madhusudan P., Wang, Su Q., Nishizono, Ryuzoh, Suzuki, Tsukasa, Wickman, Larysa T., Wiggins, Jocelyn E., Muchayi, Timothy, Fingar, Diane, Shedden, Kerby A., Inoki, Ken, Wiggins, Roger C.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2012
Teme:
Basic Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402293/
https://ncbi.nlm.nih.gov/pubmed/22773827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012030271
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