Growth-Dependent Podocyte Failure Causes Glomerulosclerosis

Podocyte depletion leads to glomerulosclerosis, but whether an impaired capacity of podocytes to respond to hypertrophic stress also causes glomerulosclerosis is unknown. We generated transgenic Fischer 344 rats that express a dominant negative AA-4E-BP1 transgene driven by the podocin promoter; a m...

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Autori principali: Fukuda, Akihiro, Chowdhury, Mahboob A., Venkatareddy, Madhusudan P., Wang, Su Q., Nishizono, Ryuzoh, Suzuki, Tsukasa, Wickman, Larysa T., Wiggins, Jocelyn E., Muchayi, Timothy, Fingar, Diane, Shedden, Kerby A., Inoki, Ken, Wiggins, Roger C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2012
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402293/
https://ncbi.nlm.nih.gov/pubmed/22773827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012030271
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