Growth-Dependent Podocyte Failure Causes Glomerulosclerosis

Podocyte depletion leads to glomerulosclerosis, but whether an impaired capacity of podocytes to respond to hypertrophic stress also causes glomerulosclerosis is unknown. We generated transgenic Fischer 344 rats that express a dominant negative AA-4E-BP1 transgene driven by the podocin promoter; a m...

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Main Authors: Fukuda, Akihiro, Chowdhury, Mahboob A., Venkatareddy, Madhusudan P., Wang, Su Q., Nishizono, Ryuzoh, Suzuki, Tsukasa, Wickman, Larysa T., Wiggins, Jocelyn E., Muchayi, Timothy, Fingar, Diane, Shedden, Kerby A., Inoki, Ken, Wiggins, Roger C.
格式: Artigo
語言:Inglês
出版: American Society of Nephrology 2012
主題:
Basic Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402293/
https://ncbi.nlm.nih.gov/pubmed/22773827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012030271
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