Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known however whether ageing, the major risk factor for sporadic AD, affects...

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Detalhes bibliográficos
Main Authors: Guix, Francesc X, Wahle, Tina, Vennekens, Kristel, Snellinx, An, Chávez-Gutiérrez, Lucía, Ill-Raga, Gerard, Ramos-Fernandez, Eva, Guardia-Laguarta, Cristina, Lleó, Alberto, Arimon, Muriel, Berezovska, Oksana, Muñoz, Francisco J, Dotti, Carlos G, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402223/
https://ncbi.nlm.nih.gov/pubmed/22488900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200243
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