Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: Sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors

Human isoprenylcysteine carboxyl methyltransferase (hIcmt) is a promising anticancer target as it is important for the post-translational modification of oncogenic Ras proteins. We herein report the synthesis and biochemical activity of 41 farnesyl-cysteine based analogs versus hIcmt. We have demons...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Majmudar, Jaimeen D., Hahne, Kalub, Hrycyna, Christine A., Gibbs, Richard A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401633/
https://ncbi.nlm.nih.gov/pubmed/21334890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.01.078
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla