Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase

N-acetyl-S-farnesyl-L-cysteine (AFC) is the minimal substrate for the enzyme isoprenylcysteine carboxyl methyltransferase (Icmt). A series of amide-modified farnesylcysteine analogs were synthesized and screened against human Icmt. From a 23-member library of compounds, six inhibitors were identifie...

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Hauptverfasser: Donelson, James L., Hodges, Heather B., MacDougall, Daniel D., Henriksen, Brian S., Hrycyna, Christine A., Gibbs, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401632/
https://ncbi.nlm.nih.gov/pubmed/16777414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.05.029
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