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New Synthetic Methodology for the Construction of 7-Substituted Farnesyl Diphosphate Analogs

Through the use of a 1,2-metalate rearrangement, six 7-substituted farnesol analogs were generated in a concise manner. This new synthetic route allowed us to quickly prepare several diverse farnesyl diphosphate analogs with interesting biological activities against mammalian protein-farnesyl transf...

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Detalhes bibliográficos
Main Authors: Placzek, Andrew T., Gibbs, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401630/
https://ncbi.nlm.nih.gov/pubmed/21699139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol201069x
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