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Synthesis and Evaluation of 3- and 7-Substituted Geranylgeranyl Pyrophosphate Analogs
Protein prenyl transferases have been a focus of anti-cancer drug discovery in recent years due to their roles in posttranslational modification of small GTP binding proteins. Attention is now turning to the development of GGTase I inhibitors. Here, we present the synthesis and biological evaluation...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2376209/ https://ncbi.nlm.nih.gov/pubmed/18321704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.02.014 |
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