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Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors
A series of phenylpropyloxyethylamines and cinnamyloxyethylamines were synthesized as deconstructed analogs of 14-phenylpropyloxymetopon and analyzed for opioid receptor binding affinity. Using the Conformationally Sampled Pharmacophore modeling approach, we discovered a series of compounds lacking...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401595/ https://ncbi.nlm.nih.gov/pubmed/22677527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.006 |
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