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Iron-overload decreases Cav1.3-dependent L-type Ca(2+) currents leading to bradycardia, altered electrical conduction and atrial fibrillation
BACKGROUND: Chronic iron-overload (CIO) is associated with blood disorders such as thalassemias and hemochromatosis. A major prognostic indicator of survival in patients with CIO is iron-mediated cardiomyopathy, characterized by contractile dysfunction and electrical disturbances including slow hear...
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401539/ https://ncbi.nlm.nih.gov/pubmed/21747058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.110.960401 |
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