Iron-overload decreases Cav1.3-dependent L-type Ca(2+) currents leading to bradycardia, altered electrical conduction and atrial fibrillation

BACKGROUND: Chronic iron-overload (CIO) is associated with blood disorders such as thalassemias and hemochromatosis. A major prognostic indicator of survival in patients with CIO is iron-mediated cardiomyopathy, characterized by contractile dysfunction and electrical disturbances including slow hear...

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Bibliografiset tiedot
Päätekijät: Rose, Robert A., Sellan, Michael, Simpson, Jeremy A., Izaddoustdar, Farzad, Cifelli, Carlo, Panama, Brian K., Davis, Mark, Zhao, Dongling, Markhani, Moniba, Murphy, Geoffrey G., Striessnig, Joerg, Liu, Peter P., Heximer, Scott P., Backx, Peter H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401539/
https://ncbi.nlm.nih.gov/pubmed/21747058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.110.960401
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