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Bacterial biosynthesis and maturation of the didemnin anticancer agents
The antineoplastic agent didemnin B from the Caribbean tunicate Trididemnum solidum was the first marine drug to be clinically tested in humans. Because of its limited supply and its complex cyclic depsipeptide structure, considerable challenges were encountered during didemnin B's development...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401512/ https://ncbi.nlm.nih.gov/pubmed/22458477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja301735a |
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