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Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide
Tamoxifen dosage is based on the one-dose-fits-all approach. The anticancer effect of tamoxifen is believed to be due to the metabolites, 4-hydroxytamoxifen (4OHtam), and 4-hydroxy-N-desmethyltamoxifen (4OHNDtam/endoxifen). These demethylated metabolites of tamoxifen have been associated with its si...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401496/ https://ncbi.nlm.nih.gov/pubmed/22562123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-2074-9 |
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