Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide

Tamoxifen dosage is based on the one-dose-fits-all approach. The anticancer effect of tamoxifen is believed to be due to the metabolites, 4-hydroxytamoxifen (4OHtam), and 4-hydroxy-N-desmethyltamoxifen (4OHNDtam/endoxifen). These demethylated metabolites of tamoxifen have been associated with its si...

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Bibliographic Details
Main Authors: Gjerde, Jennifer, Gandini, Sara, Guerrieri-Gonzaga, Aliana, Haugan Moi, Line L., Aristarco, Valentina, Mellgren, Gunnar, DeCensi, Andrea, Lien, Ernst A.
Format: Artigo
Language:Inglês
Published: Springer US 2012
Subjects:
Clinical Trial
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401496/
https://ncbi.nlm.nih.gov/pubmed/22562123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-2074-9
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